This page is not an indication page, and it was not made to be one. In healthy older people, with an ageing endpoint, no randomised trial has been carried out — what we know comes from human observation and from animal experiments. This page says so at the beginning, not at the end.
Three things of differing strength can be said about the relationship between ageing and the gut flora. The longevity market usually blurs them together. We do not.
The centenarians is measurably different: it is rich in bacteria that produce distinctive secondary bile acids not previously described. One of these exerts a strong antimicrobial effect against several multidrug-resistant pathogens.815 This is a real difference, measured repeatedly.
What must not be read into it: that this gut flora causes the long life. Someone who lives to a hundred also has a different diet, different physical activity, different medication and different living conditions — the gut flora moves together with these. Which one drives which is not something a cross-sectional observation can settle.
The microbiota of young donor mice, transferred into old mice, reversed the ageing-related changes in peripheral and brain immunity, and eased part of the age-related behavioural decline.823 The 2025 review cites similar animal experiments for physical performance, for sarcopenia and for blood formation as well.822
The effect of diet, fibre intake, fermented foods, regular exercise, sleep and stress management on the composition of the gut flora is supported by human data, and it is available today, cheaply. The Microbiota Guide discusses this in detail. The practical value of this page lies primarily here, not in the capsule.
The place of microbiota transfer therapy (MTT) within this frame: individual medical judgement, expressly experimental in character, with the absence of evidence stated openly. Not a product, not a package, not an “anti-ageing protocol”. The details are discussed in the evidence section of this page and on the scientific background page.
This is not a diagnosis and not an eligibility assessment — but in one minute it shows whether this page is for you at all.
If you are looking for a solution to a specific disease, this page is not for you. For that we have our own indication pages: IBS and IBD, Parkinson's disease, obesity and metabolism, C. difficile infection. There we can point to randomised human trials — here we cannot.
We do not start a course in the case of immunosuppression, active oncological treatment or a state following organ transplantation: with a healthy-person goal the balance of risk and benefit cannot be defended. Pregnancy and breastfeeding, frailty in old age, significant malnutrition, an unstable comorbidity and an unexplained complaint are likewise excluded — in the last case investigation is needed first.
So that you know when things happen and where the decision points are.
A free, 15-minute conversation. This is where we say — not in the small print — that you will not receive a treatment of proven efficacy, and what can and cannot be expected from this. Many people decide at this point not to begin. That is fine.
We go through the diet, the fibre intake, the physical activity, the sleep and the medication. This step gives value in itself, and its effect is better documented than that of the capsule. On request, a DynaMAP microbiome baseline.
UltraBiome may be used only after a specialist examination, under medical supervision. This is where it is decided whether it is justified to begin at all and, if so, at what dose level. Decision: if it is not justified, we stop here.
The standard arm starts with 30(X) and continues as the treating physician decides. There is no objective endpoint that we could measure — there is no laboratory value that would show “an improvement in immunosenescence”. The assessment is therefore made jointly with the treating physician, on the basis of symptoms and performance capacity.
The same order as on the timeline above. At every stage you will know what the next thing to do is.
Fill in the form or ask for a call back. In a free, 15-minute conversation we clarify what can realistically be expected from this — and what cannot. If we think this is not for you, we will say so.
→We send a link by e-mail with which you can register as a patient. At that point you receive from us a unique identifier in the P0000000 format. We record the data, and you fill in the “Goals and expectations” questionnaire — this is where an unrealistic expectation comes to light.
Diet, fibre intake, fermented foods, physical activity, sleep, stress management, medicines. This is where we start, not with the capsule, because the effect of these on the gut flora is supported by human data. On request, a DynaMAP baseline.
UltraBiome may be used only after a specialist examination, under medical supervision. The specialist decides whether the treatment is justified and which dose level comes into question.
The standard arm starts with 30(X), and after a significant increase in performance capacity it continues with 30(V). If the 30(X)-level dose does not bring the expected change, the intensive arm starts with 30(L). One packaging unit is 30 capsules.
The assessment is made jointly with the treating physician, because there is no objective endpoint. If we see no change, we say so, and we do not recommend continuing.
You do not have to decide about the whole process at once. After every step you have the option to withdraw.
| Variant | Role in the therapy | Price |
|---|---|---|
| UltraBiome 30(X) 30 capsules | The start of the standard therapy, for a minimum of 3 months, until there is a significant increase in performance capacity | €2,600 / unit |
| UltraBiome 30(V) 30 capsules | The treatment started with 30(X) is continued, if performance capacity has increased significantly | €1,250 / unit |
| UltraBiome 30(L) 30 capsules | The start of the intensive arm, if the 30(X)-level dose has not brought the expected change. Continuation of the intensive arm is decided individually, together with the treating physician and with us — we give information about this at the specialist consultation. | €7,800 / unit longer production time — capacity must be agreed before ordering |
Every variant is 30 capsules, minimum order 1 packaging unit. Only under medical supervision, after a specialist examination. You will find the full data sheet on the UltraBiome page.
| Item | Included? |
|---|---|
| Call back and pre-screening (15-minute conversation) | yes — free of charge |
| Appearing in person | is not necessary — the process is remote throughout |
| Exposome consultation | separate item: €185 |
| DynaMAP microbiome profile | can be ordered separately: €325 (professional) or €575 (comprehensive) |
| The capsules in the packaging unit ordered | yes — at the price in the table above |
| Shipping cost | no — the delivery charge is separate |
| Follow-up during the course | yes |
| Joint closing assessment and tapering-off plan | yes |
| Examination by the treating physician, laboratory tests | no — these take place at your own healthcare provider |
The same donor microbiota, processed in a certified laboratory, on two arms — the starting dose of the standard and of the intensive therapy differs.
The UltraBiome preparation is built on donor material from ultra-athletes and elite athletes. It is worth knowing what this choice is based on — and what it is not.
What has been observed. The gut flora of elite athletes shows greater diversity and a different metabolite profile: more species producing short-chain fatty acids, more active amino acid synthesis.813 And what goes together with endurance performance is not a single species but the stability of the gut flora.814 The relationship between exercise and the gut flora is two-way: training shapes the flora, and the flora in turn acts back on fatigue and performance.812
What must not be read into it. That an athlete's gut flora causes the performance. Someone who trains ten hours a week also has a different diet, different sleep, a different body composition and different circulation. The gut flora moves together with these. The step that transferring an athlete's gut flora would improve the recipient's performance is not proven in humans.
Short answer. In healthy older people, with an ageing or immunosenescence endpoint, no randomised human trial is available. What we know comes from two sources: human observations, which show association, and animal experiments, which show causation — but in mice. That is why this page is a treatment recommendation, not an indication.
Human observation. The gut flora of centenarians is rich in the production of distinctive secondary bile acids; one of these has a strong antimicrobial effect.815 In elite athletes, greater diversity and a different metabolite profile can be measured,813 and it is the stability of the flora that goes together with endurance.814 These are cross-sectional observations: they do not prove a cause.
Animal experiment. In old mice, the microbiota of young donor mice reversed the ageing-related immune and brain changes and eased part of the age-related behavioural decline — but the effect was selective and did not extend to every indicator examined.823
What the 2025 review says. The authors cite several animal-experimental results for physical performance, for sarcopenia, for cognition and for blood formation. The human clinical evidence, by contrast, still comes from gastrointestinal and certain neurological conditions, not from healthy older people. Their closing conclusion is that the procedure is promising, but that “its full viability and efficacy are still under investigation”.822
There is no guideline recommendation. Not a single professional guideline recommends microbiota transfer for an ageing or longevity purpose. We say this even though it speaks against our own service.
Every donor goes through our DSQ donor screening framework.
Every capsule we ship carries a LOT number (a manufacturing batch identifier), so it can be traced back to the donor at any time.
In the case of immunosuppression, active oncological treatment or a state following organ transplantation we do not start a course. In disease the balance of risk and benefit can be weighed; with a healthy-person goal it cannot.
We do not use a “biological age” measure, because there is no validated laboratory value that would show an improvement in immunosenescence. Anyone who promises you such a thing is claiming more than they can measure.
UltraBiome may be used only after a specialist examination, under medical supervision. We do not start a protocol without a treating physician, and we deliver the capsules under the “to the doctor's hand” system.
Mild, transient complaints are common: bloating, abdominal discomfort, transient diarrhoea, a slight rise in temperature. A serious event is rare. With a healthy-person goal, however, every risk is harder to defend, because there is no proven benefit to set against it.
If you are a treating physician, or the patient asks you for an opinion: treatment follows the MTT Clinical Protocol Guide v7.1 which sets out patient selection, dose determination, the rules of escalation and gradual tapering, the requirements of donor screening and the steps of follow-up. Please note that there is no guideline recommendation for an ageing indication, and we regard this use as individual medical judgement.
The scientific background page sets out, point by point, what has been observed in humans, what the animal experiments show, and what can be inferred from this — and what cannot. Beside every statement there is the reference and its summary.
Write briefly about what you would like to achieve and what you are doing for it today. We will look at whether it makes sense to start in your case — and if we think it does not, we will say so too.
MicroBiome Bank does not sell products; it connects donors and recipients by providing professional medical services: it organises the recruitment of donors and their screening in a certified laboratory, the stool tests, and the processing of the screened donation into capsule form. The contents of the capsules remain the property of the donor until the recipient has paid in full. The brand names of the services serve to make them easier to remember. We deliver the capsules “to the doctor's hand”, and they are to be used under the guidance of a treating physician. For detailed information, please contact us.
The MicroBiome Bank service is not a substitute for professional medical advice, diagnosis or treatment. The decision to use it rests in every case with the treating physician.