The market promises weight loss. The studies do not show this: microbiota transfer therapy (MTT) had no effect on body weight or on the body mass index. What there are data on is a few markers of metabolism — blood sugar, HbA1c, insulin level and HDL cholesterol — and even there the effect is small. This page says so before it asks anything of you.
The gut flora has a say in metabolism. That does not mean that replacing it solves obesity.
If you have been struggling with your weight or your blood sugar for years, you have probably already heard that “the gut flora is to blame”. The picture is more nuanced than that — and that is precisely why it is worth reading this page through before you give anyone money for it.
There is no doubt that gut bacteria take part in metabolism. Some species extract more energy from the same food, they increase the permeability of the intestinal wall, and the bacterial cell-wall components that reach the bloodstream maintain a persistent, low-grade inflammation. Others — for example Akkermansia muciniphila — strengthen the gut barrier. And the short-chain fatty acids (acetate, propionate, butyrate) directly regulate fat metabolism.810
It is also true that gut flora from a lean donor temporarily improved insulin sensitivity in men with metabolic syndrome — this was the 2012 study from which the whole field started.194 The continuation, however, also showed the limit: the effect had disappeared by eighteen weeks, and it appeared only in those whose gut flora diversity was low to begin with.712
The aim of MTT here is therefore not weight loss, but influencing a few measurable markers of metabolism, alongside the established treatment. What exactly was measured, what came out of it and how reliable it is, is discussed in the evidence section of this page and on the scientific background page — together with the numbers.
This is not a diagnosis and does not replace an internal medicine examination — but in one minute it shows whether it is worth getting in touch with us.
In the case of an active or previous eating disorder we do not start a course. A page that deals with body weight inevitably reaches readers whose relationship with their own body is damaged. If you are in such a situation, our service does not help, and it may even harm: please turn to a specialist experienced in eating disorder care. We are glad to help you find one.
In the same way, specialist care comes first in the case of unexplained, significant unintentional weight loss, recent or planned bariatric surgery, insulin-treated unstable diabetes without close supervision, severe immune deficiency or active oncological treatment, and in the case of pregnancy and breastfeeding.
So that you know when things happen and where the decision points are.
A free, 15-minute conversation, then registration. We record the baseline metabolic values measured by your treating physician: fasting blood sugar, HbA1c, insulin, blood lipids, waist circumference. Without these there will later be nothing to compare against.
We go through the diet, the physical activity, the sleep and the medication, and we clarify the goal. Decision: after the specialist examination it is decided whether starting is justified at all — and if it is not, we will say so.
UltraBiome capsule at the dose level and for the period determined by your treating physician. The established treatment — diet, exercise, medication — continues unchanged alongside it.
We repeat the same laboratory tests. Decision: has anything moved measurably. If not, we say so, and we do not recommend continuing. According to the studies the effect does not persist beyond twelve weeks anyway — this has to be known in advance.
The same order as on the timeline above. At every stage you will know what the next thing to do is.
Fill in the form or ask for a call back. In a free, 15-minute conversation we clarify whether it makes sense to start in your case — including what you can realistically expect.
→We send a link by e-mail with which you can register as a patient. At that point you receive from us a unique identifier in the P0000000 format. We record the baseline laboratory values and the “Goals and expectations” questionnaire.
We go through the environmental and lifestyle exposures: diet, fibre intake, physical activity, sleep, medicines. Their effect on metabolism is orders of magnitude better documentedthan that of MTT — this is why we start here, not with the capsule. A DynaMAP microbiome baseline if you wish.
UltraBiome may be used only after a specialist examination, under medical supervision. This is where it is decided whether the treatment is justified, at what dose level and for how long. If it is not justified, this is where we stop.
The course runs at the determined dose level, under the direction of the treating physician. The established treatment is neither replaced nor modified. One packaging unit is 30 capsules.
In weeks 12–16 we repeat the laboratory tests and compare them with the baseline values. If nothing has moved, we say so. The capsule is tapered off gradually, under medical direction.
You do not have to decide about the whole process at once. After every step you have the opportunity to assess the results achieved.
| Step | What we provide | Price | Must you continue? |
|---|---|---|---|
| 1. Call back and pre-screening | A 15-minute conversation, clarifying suitability | free of charge | no |
| 2. Exposome consultation | Assessment of environmental and lifestyle exposures, setting goals together (with a DynaMAP baseline if wanted) | €185 the DynaMAP can be ordered separately: €325 (professional) or €575 (comprehensive) | no |
| 3. UltraBiome 30(V) course 30 capsules / packaging unit | A high-density preparation, at the dose level and for the period determined at the specialist examination, under medical supervision | €1,250 / unit min. order 1 unit | – |
| Item | Included? |
|---|---|
| Call back and pre-screening (15-minute conversation) | yes — free of charge |
| Exposome consultation | separate item: €185 |
| DynaMAP microbiome profile | can be ordered separately: €325 (professional) or €575 (comprehensive) |
| Appearing in person | is not necessary — the process is remote throughout |
| The capsules in the packaging unit ordered | yes — at the price in the table above |
| Shipping cost | no — the delivery charge is separate |
| Follow-up during the course | yes |
| Joint closing assessment and tapering-off plan | yes |
| Examination by the treating physician, laboratory tests | no — these take place at your own healthcare provider |
Donor microbiota processed in a certified laboratory — in a metabolic indication it is the high-density preparation that comes into question.
The evidence situation for body weight and for the metabolic markers is not the same. This is the most important sentence to take away from this page. The most recent meta-analysis pools nine randomised trials, 303 patients in total — which is few, and on most of the endpoints it does not produce a significant result.821
Body weight and BMI: no effect. For body weight the difference was 2.72 kg compared with the control group, but with such wide uncertainty (95% CI −4.74 … +10.18) that it cannot be interpreted in any direction; for BMI the situation is the same.821 A 2025 analysis pooling eleven trials also found only a non-significant trend.809 We therefore do not promise weight loss, because there is nothing to base it on.
Metabolic markers: a small but measurable shift. Fasting blood sugar, HbA1c, insulin level and HDL cholesterol improved significantly — each of them to a small degree.821 The improvement in insulin sensitivity was also demonstrated by two earlier, well-documented studies.194, 712 One American study, by contrast, on these same endpoints found nothing, even though the transplanted flora did become established.804
Durability is the weakest point. In the follow-up beyond twelve weeks the meta-analysis found no difference on any endpoint between the two groups.821 In the 2017 mechanism study the improvement measured at six weeks had disappeared by eighteen weeks.712 One exception is known: in the four-year follow-up of a study in adolescents the body mass index did not differ, but the waist circumference, the body fat percentage and the inflammatory marker did.808
The accompanying treatment matters. Where fibre supplementation or a lifestyle intervention accompanied the MTT, there was a result; where it did not, often there was none.805, 806 This is the most important practical conclusion: the capsule does not make up for diet and exercise — at most it supplements them.
There is no guideline recommendation. No professional guideline dealing with metabolic disease recommends MTT today in obesity or type 2 diabetes. We say this even though it speaks against our own service.
Every donor goes through our DSQ donor screening framework.
Every capsule we ship carries a LOT number (a manufacturing batch identifier), so it can be traced back to the donor at any time.
We ask about it during the pre-screening. In the case of an active or previous eating disorder we do not begin a course, but refer you to specialist care. This is not a formality: this is where a service dealing with body weight can do the most harm.
The treatment of diabetes and of metabolic disease we neither touch nor replace. Only the treating physician may decide about stopping a medicine or changing a dose.
We tie the assessment to a baseline and a follow-up laboratory test. In weeks 12–16 the numbers decide, not the impression. If nothing has moved, we say so.
In the studies only mild events occurred: a slight rise in temperature, headache, nausea, transient diarrhoea, abdominal pain. No serious side effect has been described. In an immunodeficient patient the risk requires individual assessment.
The process breaks down into four stages, and at the end of each there is an exit point. We do not build on automatic continuation.
Step 1 — Pre-screening and baseline measurement. A free, 15-minute conversation, then registration. We record the baseline values measured by your treating physician: fasting blood sugar, HbA1c, insulin, blood lipids, waist circumference, body weight. Without these there will be nothing to compare with at the end of the course — and it is precisely this measurability that makes this page defensible at all.
Step 2 — Exposome consultation and DynaMAP (optional). We go through the diet, the fibre intake, the physical activity, the sleep and the medication. In the studies microbiota transfer produced a result where fibre supplementation or a lifestyle intervention accompanied it — which is why this step is not a formality. The consultation costs €185, and the DynaMAP can be ordered separately.
Step 3 — Specialist examination and UltraBiome course. UltraBiome may be used only after a specialist examination, under medical supervision; the dose level and the length of the course are decided by the doctor. One packaging unit is 30 capsules, at a price of €1,250. The established treatment continues unchanged throughout.
Step 4 — Follow-up measurement, gradual tapering off. In weeks 12–16 we repeat the same laboratory tests. If the values have measurably improved, we decide about continuing together with your treating physician; if not, the capsule is tapered off gradually, under medical direction.
If you are an internist, a diabetologist or a general practitioner, or the patient asks you for an opinion: treatment follows the MTT Clinical Protocol Guide v7.1 which sets out patient selection, dose determination, the rules of escalation and gradual tapering, donor screening requirements and the follow-up steps. Referring a patient requires no separate agreement: a single message is enough.
The scientific background page works through, point by point and separately for body weight and for the metabolic markers, what the trials measured, what came out, where the uncertainty lies and what the alternative is. Beside every statement you will find the reference and its summary.
Write briefly about what metabolic abnormality has been diagnosed in you, and what has been tried so far. We will review whether it makes sense to start in your case — and if we see that it does not, we will say so.
MicroBiome Bank does not sell products; it connects donors and recipients by providing professional medical services: it organises the recruitment of donors and their screening in a certified laboratory, the stool tests, and the processing of the screened donation into capsule form. The contents of the capsules remain the property of the donor until the recipient has paid in full. The brand names of the services serve to make them easier to remember. We deliver the capsules “to the doctor's hand”, and they are to be used under the guidance of a treating physician. For detailed information, please contact us.
The MicroBiome Bank service is not a substitute for professional medical advice, diagnosis or treatment. The decision to use it rests in every case with the treating physician.